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Zonisamide

She's a talented chef, and he's a famous actor. When their fates collide, what will happen? Audrey Fuentes is in love with her childhood friend and superstar, Shane Vargas. When her parents died in a plane crash, she was forced to live on her own until she was given a chance to be with the man she loves. Shane's parents fly back to the country to attend their wedding, which was arranged for a long time before her parents passed away. Just like any other bride, Audrey was excited to walk on the red carpet and meet up with the man of her dreams at the end of the aisle. What happened on the day of her wedding ceremony was nothing like what she envisioned. Shane left for another country after signing their marriage contract the day before the ceremony. To make things worse, Audrey gets involved in the accident when she's on her way home on the same day. Five years passed, and so Audrey confronted the man. She gathered enough courage to propose an annulment when she returned. Will she be able to completely move on and let go of her love? After several years, her heart still beats so fast whenever she sees him. The problem is, Shane is already head over heels with someone else. Audrey Fuentes is Shane's deserted bride.

9.4

117 Chapters

Alphas Broken Mate

** English is not my first language, and I know there is some grammar not being right. But I try my best.** Note to readers. ** this book/novel, contains sexual as well as abusive episodes.** Lina is a 17-year-old orphan living in a foster home, her life is what she think like living in hell. until she one day at school meet the new guy Alex. for some reason he calms her, make her feel things she thought she never had. Alex is 18 and the future Alpha from the Moon Stone Pack. he has been gone for 3 years for training and to learn. Alex is ready for his mate but hasn't found her yet. until he sees the quiet strange girl no one talks to. what will their story be? will he repair his broken mate? is she just a human? if not what exactly is she.

66 Chapters

Nanny and the Alpha Daddy

I’m a new grad human in huge debt, and cheated by my Omega bf. When I got wasted in a bar, I didn’t expect to have the best sex ever. And the very next morning, I also didn’t expect to wake up and find my ONS hookup was my bf's Alpha billionaire BOSS…. How things are going to turn out after I accidentally became his 5yo daughter's live-in nanny?____________How did this happen? How did I wind up finally becoming employed, only for it to turn out that my new employer was the same person who I had a one night stand with just two nights ago?“I didn’t know that you would be the employer. If I had known, I wouldn’t have applied….”“It’s alright. I knew it was you when I hired you. I did it on purpose.” I scrunched my eyebrows together. “What do you mean?”

9.6

252 Chapters

The Biker’s Mafia Princess

Angel Moretti. He was the love of my life. I always knew he was ever since we were kids. We did everything together. His name is Ryder ‘Savage’ Jackson. He was my world, my everything. Until he brutally ripped my heart from my chest three years ago. He tore my heart to shreds when he humiliated me by claiming another woman in his clubhouse, in the same bed we once shared. Savage by name, Savage by nature. He didn’t even give me a chance to tell him the news I had just accused me of cheating. Me, Angel Moretti. Like I would ever do that to him. So I ran, I ran from the pain he caused me. Ran from my family. Not wanting to be seen as the disgrace, but mainly to save him and his MC from annihilation. So I fled with the life we created growing inside of me. But all good things must come to an end. When he walks into my bar three years later. So what do I? Do I run? Or face the man who destroyed me? What could go wrong? Well, everything apparently. Ryder ‘Savage’ Jackson. She was my Angel, my goddess sent to me from heaven and I fucked it up. I claimed someone I shouldn’t have and paid dearly for it. I was a damn fool to believe the lies and bullshit. Missing out on the most precious gift Angel could give me. But I will make it right. Angel Moretti thinks she can get away from me with my kid. She has another thing coming, especially when I claim them both as mine. She will have no choice but to move back home with me. She may be a Mafia Princess, but she is mine!

9.8

493 Chapters

The Alpha Claimed Me Deeply

She's trying to escape. He's looking for revenge. She stumbles. He catches. She holds a secret. He wants to unravel it. It's impossible for them to be mates. But destiny had other plans. Xavier Knight thinks having a mate makes one weak. But can he really resist the bond that has entwined the two so deeply? Especially when he needs to have a taste of her to calm his raging beast? Her taste alone has become an addiction he craves severely, so how long can he hold off from marking her as his? Warning! MATURE CONTENT!

9.8

81 Chapters

The Lycan Prince’s Puppy

“You’re mine, little puppy,” Kylan growled against my neck. “Soon enough, you’ll be begging for me. And when you do—I’ll use you as I see fit, and then I’ll reject you.” — When Violet Hastings begins her freshman year at Starlight Shifters Academy, she only wants two things—honor her mother’s legacy by becoming a skilled healer for her pack and get through the academy without anyone calling her a freak for her strange eye condition. Things take a dramatic turn when she discovers that Kylan, the arrogant heir to the Lycan throne who has made her life miserable from the moment they met, is her mate. Kylan, known for his cold personality and cruel ways, is far from thrilled. He refuses to accept Violet as his mate, yet he doesn’t want to reject her either. Instead, he sees her as his puppy, and is determined to make her life even more of a living hell. As if dealing with Kylan’s torment isn’t enough, Violet begins to uncover secrets about her past that change everything she thought she knew. Where does she truly come from? What is the secret behind her eyes? And has her whole life been a lie?

9.9

380 Chapters

How Does Zonisamide Work To Control Seizures?

4 Answers2026-01-23 12:16:01

Zonisamide works through a few different tricks that add up to calmer, less excitable brain networks. At a basic level I like to think of it as lowering the volume on overly chatty neurons: it blocks voltage-dependent sodium channels which reduces the ability of neurons to fire repetitively and sustain high-frequency bursts. It also inhibits T-type calcium channels, which is especially important in the thalamocortical circuits that can generate seizure rhythms. Those two effects together make it harder for an unstable patch of cortex to propagate a seizure.

On top of that, zonisamide has a mild carbonic anhydrase–inhibiting effect, which slightly changes the acid-base balance in the brain and can suppress excitability in some people. There are suggestions it modulates inhibitory and excitatory neurotransmission too, nudging the balance toward inhibition. Clinically that translates into its common use for focal (partial) seizures as adjunctive therapy, and it has a long half-life so dosing is fairly convenient. For me, the most memorable practical points are the risks — kidney stones, metabolic acidosis, and possible rash — so I always mentally bookmark the monitoring steps and safety checks when I think about it.

Does Zonisamide Interact With Common Antidepressants?

4 Answers2026-01-23 23:24:26

I get nerdily curious about drug interactions, so I dug into zonisamide and common antidepressants and wanted to share what I've learned in plain talk. Zonisamide is an anticonvulsant that also changes sodium/calcium channel activity and has some carbonic anhydrase inhibition — that biochemical mix means it can interact with other brain-active meds in a few predictable ways. The big themes are: increased central nervous system effects (think drowsiness, dizziness, slowed thinking) when combined with sedating antidepressants like tricyclics or mirtazapine; possible changes in zonisamide blood levels if you’re on antidepressants that affect liver enzymes; and the special issue of seizure threshold with drugs like bupropion which can increase seizure risk independently.

Clinically, some SSRIs and SNRIs (fluoxetine, fluvoxamine, paroxetine, etc.) can alter liver enzyme activity and theoretically raise or lower zonisamide concentrations, so dose adjustments or extra monitoring sometimes happen. There are rare case reports suggesting serotonin-related problems when multiple serotonergic agents are stacked, though zonisamide itself isn’t a classic serotonergic drug. I’ve seen clinicians be cautious: watch for worsening side effects, check labs if symptoms appear, and be especially careful when someone is starting, stopping, or changing doses. For me, the take is simple — interactions are possible but usually manageable with attention and communication; I’d rather be cautious than surprised.

What Are The Most Common Side Effects Of Zonisamide?

4 Answers2026-01-23 09:01:00

I've watched a close friend start zonisamide and noticed the side effects roll in like little warning flags. The most common ones people talk about are drowsiness and dizziness — they make driving and late-night study sessions awkward. Appetite can drop, and weight loss sometimes follows; my friend went from snacking normally to forgetting lunch entirely. Nausea and stomach upset are pretty frequent too, and a handful of folks complain about a mild headache or trouble concentrating.

Beyond the everyday complaints, there are a few things I learned to keep an eye on: zonisamide can make you more prone to kidney stones and can cause a drop in bicarbonate levels (so-called metabolic acidosis), because it has some carbonic anhydrase inhibition. That means staying hydrated is actually one of the simplest, most practical precautions. Rash and sleep changes happen for some people, and though less common, mood swings or depression deserve attention. In short, it worked for seizure control for my friend but came with trade-offs that needed monitoring — I stayed vigilant and kept hydrated, and that helped a lot.

Can Zonisamide Cause Weight Loss Or Appetite Changes?

4 Answers2026-01-23 12:56:41

Quick heads-up: zonisamide can definitely change appetite and cause weight loss for some people, though it’s not guaranteed. I noticed this after reading patient reports and chatting with folks in medication support groups — some describe mild appetite suppression and gradual weight loss, while others barely notice a change. The drug can cause nausea, taste changes, or a general lack of interest in food, which are easy contributors to losing a few pounds over weeks to months.

Beyond the stomach stuff, zonisamide affects the brain in ways that can reduce cravings or make eating feel less rewarding, and because it’s a sulfonamide-related anticonvulsant, metabolic shifts can happen too. If weight loss is rapid or accompanied by mood changes, low energy, or dehydration, that’s when I’d flag it as important to talk about with a clinician. Nutritional strategies like small frequent meals, calorie-dense snacks, or protein shakes helped friends I know who experienced it. Overall, I’d keep an eye on trends, log weight weekly, and treat any changes seriously but calmly — it’s manageable with awareness and small adjustments, and it gave me a sense of being proactive rather than worried.

Is Zonisamide Safe During Pregnancy And Breastfeeding?

4 Answers2026-01-23 14:28:20

I get why this question keeps popping up — pregnancy and nursing feel like a minefield when you're on any medication. From what I’ve dug into and seen people discuss, zonisamide doesn’t have a big, robust body of human-pregnancy data behind it, so clinicians tend to be cautious. Animal studies showed potential risks at higher doses, and human data are limited and mixed, so many places classify it as a drug where risks can’t be ruled out. The bottom line most doctors stress is that uncontrolled seizures during pregnancy can be more dangerous than potential drug risks, so abrupt stopping is rarely advised.

If someone is planning pregnancy, the usual practical approach I’ve heard is preconception planning: discuss dose minimization, consider safer alternatives if appropriate, and take folic acid because many antiseizure meds increase neural-tube defect risk. Also watch out for combination therapy — using multiple antiseizure drugs (especially valproate) raises malformation risk a lot more than single drugs. In short, it’s a balancing act: seizure control versus uncertain fetal risk, and having a neurologist and obstetrician coordinate care makes a huge difference. I personally feel peace of mind when there’s a clear plan and close monitoring during pregnancy.

How Much Zonisamide Should An Adult Take For Epilepsy?

4 Answers2026-01-23 11:25:42

Let me walk you through the usual approach to zonisamide dosing and what I watch for when someone I care about is starting it.

For most adults, doctors often start around 100 mg per day, commonly given as 50 mg twice daily, then increase the dose slowly. Typical maintenance doses sit between 200 and 400 mg per day depending on how well seizures are controlled and how the side effects look. Clinicians frequently titrate by about 100 mg each week or so, with 400 mg/day generally considered the upper limit in routine practice. That outline changes if someone has reduced kidney function or other medications that interact.

Safety matters a lot to me: zonisamide is a sulfonamide-related drug, so people with sulfa allergies, a history of kidney stones, or significant renal impairment need special consideration. Common side effects include drowsiness, dizziness, decreased appetite, and sometimes cognitive slowing or mood changes. There’s also a risk of metabolic acidosis and kidney stones, so periodic labs and hydration are useful. I found that keeping a medication diary helped notice patterns early, and talking openly with the prescriber about sleepiness or mood shifts makes tweaks much easier.