Can Any Character Defeat Itachi Eternal Mangekyou Sharingan?

For me, the idea of Itachi wielding an Eternal Mangekyō Sharingan and being untouchable is one of those deliciously dramatic what-ifs that keeps fandom debates alive. If we accept the premise that Itachi actually had an Eternal Mangekyō — or if we mean the version of his eyes later used by Sasuke — the baseline is terrifying: mastered genjutsu, an uncanny intellect, Susanoo equipped with the Totsuka Blade and Yata Mirror, plus those microsecond reaction times. That combo makes a single-on-one showdown staggeringly difficult for most opponents, but it certainly isn’t an absolute, immutable trump card. Breaking it down, there are a few distinct routes to beat someone with that toolkit. One is nullifying or avoiding the eyes entirely: long-range attacks, space–time techniques, or battlefield control that prevents visual contact or line-of-sight. Another is overpowering or bypassing Susanoo — either with sealing jutsu, dimensional techniques, or sheer destructive force that negates the Totsuka/Totsuka’s metaphysical sealing (which is rare). A third path is immune or highly resistant minds: characters with Six Paths-level chakra, those granted near-divine protection, or fighters who simply cannot be trapped by genjutsu because of their nature, will, or special ocular powers of their own. Inside 'Naruto', obvious candidates are people who sit above standard shinobi scaling: figures like Kaguya or Hagoromo could trivialize Itachi’s options through reality-warping and multi-dimensional techniques. Sasuke with his own Eternal Mangekyō/Rinnegan setup can contest Itachi on equal footing because of both ocular parity and tactics like Amenotejikara. Naruto with Six Paths chakra — and especially combined with a massive life-force advantage or sealing tools — can resist genjutsu and trade blows long enough to force a stalemate or win. Madara or Obito wielding Rinnegan/ten-tails power could also overwhelm Susanoo defenses with world-altering attacks. Outside the series, if you allow crossover hypotheticals, characters who erase inevitabilities (reality warpers, soul-sealers) would beat Itachi’s ocular supremacy simply by changing the battlefield rules. Ultimately, Itachi’s Eternal Mangekyō would be one of the most fearsome tools a fighter could carry, but it’s not invincible — it’s a set of advantages that can be countered by line-of-sight denial, higher-tier ocular or chakra powers, sealing/erasure techniques, or direct reality-level threats. I love imagining how a clever opponent would choreograph a takedown — it’s the kind of tactical duel that makes me want to rewatch 'Naruto' and scribble strategies in the margins.

Okay, quick take: yes — plenty of characters could realistically beat Itachi if he had an Eternal Mangekyō Sharingan, especially if you accept high-tier or godlike opponents. My short mental top list includes: Sasuke with a rival Eternal Mangekyō/Rinnegan setup, Naruto when armed with Six Paths chakra and sufficient sealing tools, Madara or Obito in Ten-Tails form, and cosmic-levels like Kaguya who rewrite dimensions. Why? Mostly because Itachi’s strengths are specific: genjutsu mastery, the near-absolute defense/offense of Susanoo with Totsuka/Yata, and surgical intelligence. To overcome that you need either to prevent eye contact (space–time attacks, long-range counters), be immune/resistant to genjutsu (Six Paths-level chakra or unique mental fortitude), or bring powers that neutralize Susanoo’s metaphysical weapons (sealing, reality manipulation, or overwhelming destructive force). I get a kick out of imagining these fights — seeing strategy and raw power clash is what keeps me theorizing late into the night, and some matchups would be downright cinematic.