ONE NIGHT STAND BETWEEN BEST FRIENDS Salma Gascon falls in love with her best friend on the day he saves her at a frat party. On graduation night, Salma confesses her feelings and Brandon McLean admits he feels the same. By morning, he is gone and has erased her from his life. Weeks later, Salma learns she is pregnant. When she goes to him, she finds him with the woman who once hurt her. He rejects her and the child. At home, Salma hears plans to force her into aborting her child. She runs away without looking back.
Years later, Salma returns as a successful surgeon and a daughter that looks just like Brandon. Brandon finds himself in need of her help but when they finally see each other, old feelings of lust, desire and also hate rise up. They become locked in a custody battle for their daughter, Leona. But Leona unexpectedly falls sick and they are left with a choice. To keep fighting their attraction for each other or to fight to stay together.