The experiment.
Every wolf family have lost a member or more to the rogue sickness, James was no different, he never told us who's the person he lost, or how they got the sickness, but we knew they meant a lot to him.
Now years later, we're so close to finding a way to save the rogues from their sickness, we only had dead bodies to study before, but with the alpha's blessing and resources, we have managed to catch a live rogue. She wasn't anyone, she was someone who was really important to the alpha, to the pack, she was special and different, yet another reason to complete this experiment.