These crossovers are wild, honestly. The main thing I notice is writers spend a lot of energy trying to balance magic with biotics and tech. It's never just 'Harry casts Avada Kedavra and wins,' which would be boring anyway. Usually, the magic system gets a sci-fi rework—maybe spellcasting draws on eezo exposure, or wand cores are replaced with omni-gel components. The conflict often isn't about who has the bigger gun, but about clashing worldviews. How does a wizard raised in secrecy react to the Citadel Council? Does Shepard see Hogwarts as a strategic asset or a security nightmare? The fun ones make Harry's outsider status from the Wizarding World actually help him integrate into the Normandy crew; he's already used to being the odd one out. I stumbled on one where Hermione and Mordin Solus geeked out over magical theory versus scientific method for chapters, and that was the real plot.
Sometimes the power scaling gets out of hand, though. I've dropped fics where Harry becomes an all-powerful biotic-wizard hybrid in three chapters, steamrolling every Reaper. The good stuff uses the limitations of each system to create tension—like, magic might not work in a vacuum, or biotics could be useless against an intangible Dementor. That's where the interesting conflicts arise, from the weaknesses, not just stacking powers.