Stumbling into a cryptic with the clue 'desires' lights me up every time because it's one of those definitions that hides so many friendly little synonyms. I usually start by thinking of short, common words a setter would love: 'wants' (5), 'yens' (4) and 'longs' (5) are my go-tos. 'Yens' is especially fun — it's compact, slightly literary, and a favourite in British-style puzzles. Beyond that, 'craves' (6), 'yearns' (6) and 'lusts' (5) crop up when a clue needs a stronger or more specific sense.
When I'm building a grid mentally I also consider surface and wordplay. 'Desires' can be the straight definition, but it can also be disguised in a double definition, or be clued by an anagram/misdirection. For a hidden clue you might see something like "seasON S FOR dinner" hiding 'onsfor' — okay, that's silly, but setters love nesting letters. Practical tip: if the enumeration is short, reach first for 'yens' or 'wants'; if it's longer, try 'yearns', 'craves' or 'wishes'.
I often jot down all likely synonyms and try them against crossing letters. That saves time and keeps me from getting tunnel vision. Personally, when I see 'desires' in a puzzle, 'wants' is the instant feel — reliable, flexible, and oddly comforting.