I'm always surprised when people recommend the same five or six big titles for this, like they've never dug beyond the seasonal charts. The romantic comedy element in a harem setup really lives or dies on whether the protagonist has a personality beyond being a convenient blank slate. Shows like 'Nisekoi' get the comedy right with the whole fake relationship and key mystery, but the romance stretches so thin across its huge cast that it barely qualifies as a mix by the end—it's mostly just gags. For a blend that actually feels balanced, 'The Quintessential Quintuplets' works because the comedy stems from the girls' distinct, often clashing personalities (the tutoring premise forces actual conversations), and the romance, while divided, has a clear endgame that gives all the fluffy and tense moments weight. The jokes about their studies and rivalry don't feel disconnected from the romantic tension.
On a completely different wavelength, 'Ouran High School Host Club' is the classic for a reason, but it flips the script. The 'harem' is a business arrangement, and the comedy is sharp, satirical, and character-driven. The slow-burn romantic through-line with Tamaki works precisely because it isn't the sole focus; it emerges from the chaos, which feels more natural than a show where every interaction is a blatant 'who will he choose' signal. The humor serves the characters, and the romantic moments feel earned, not just scheduled. It's a different approach to the mix, where the comedy is the vehicle and the romance is the passenger, rather than two separate tracks awkwardly merged.
A less obvious pick would be 'Saekano: How to Raise a Boring Girlfriend'. It's meta, it's about creating a game, and the comedy is incredibly niche and insider-y, poking fun at otaku culture and development hell. The romantic elements are woven into the characters' passions and creative conflicts, which makes the progression feel unusually substantive for the genre. The final seasons actually commit to a resolution, which is rare. So the 'best mix' might depend on whether you want broad situational gags or a more integrated, character-driven humor that directly fuels the romantic subplots.