like, the old DeviantArt days, so my perspective on this might be a bit crusty. Honestly, the perennial favorite that dominates tags on AO3 is Zim/Dib, no question. The sheer volume of enemies-to-whatever content is staggering, ranging from crackfics where they accidentally become roommates to genuinely poignant explorations of mutual obsession. It's the backbone of the fandom's fic output, really. People get super creative with the power dynamics, whether Zim's still trying to conquer Earth or they've reached a weird truce.
Beyond that, you get a solid chunk of Dib/Gaz. That one always felt a bit more divisive to me—some readers love the dynamic of the intense, weird brother and the deeply annoyed, possibly psychic sister, while others find it steps a bit too far into uncomfortable territory. The fics for this pairing often lean into psychological horror or dark comedy, which fits the show's vibe.
I have a soft spot for the more out-there, background pairings, honestly. Fics centered on The Almighty Tallest, Red and Purple, are their own little niche. It's all messy codependency, galactic empire politics, and a lot of bickering. You don't see as many of them, but when you find a good one, it's like uncovering a weird little artifact. And let's not forget the robot-centric stuff; Gir/Computer or even Gir/Moose (yes, really) exist in a bizarre, crack-filled corner of the internet. My main advice is to filter heavily by trope—the quality and tone vary wildly, so finding tags like 'slow burn' or 'canon-typical violence' will save you from wading through a lot of nonsense.