Spider-Man's loneliness in the comics isn't just about him swinging solo through New York—it's baked into his origin. Peter Parker loses Uncle Ben, carries that guilt, and even when he's surrounded by friends like MJ or Harry, there's this weight of responsibility that isolates him. The whole 'great power, great responsibility' thing means he can't fully let anyone in; he's always holding back to protect them. Even in team-ups with the Avengers or the Fantastic Four, he's the quippy outsider who never quite fits. It's why stories like 'Kraven's Last Hunt' hit so hard—they lean into that isolation, showing how the mask both saves and suffocates him.
And then there's the civilian side: Peter's perpetually broke, juggling jobs, and plagued by bad luck. The Parker luck isn't just a gag—it reinforces his loneliness. When he reveals his identity to someone (like Aunt May in 'Civil War'), it often backfires spectacularly. Even Miles Morales, who shares the Spider-Man legacy, deals with his own version of this—proving it's less about the person and more about the mantle. The suit might be spandex, but it’s also a straitjacket.