Look, if we're talking Thomas Wolfe and the South, the answer's gotta be 'Look Homeward, Angel' and maybe 'Of Time and the River'. The first one is soaked in Asheville, North Carolina – it's basically his thinly-veiled autobiography as Eugene Gant. You get the boarding house, the stonecutter shop, the whole feel of a specific Southern town straining against itself. The prose is this torrent of memory and sensory detail, all heat and dust and longing. It’s less about historical events and more about the atmosphere of a place.
'Of Time and the River' continues Eugene's story, but a lot of it moves north to Harvard and Europe. The early sections, though, they're steeped in that same Southern soil. The descriptions of the land and the people have a mythic, almost obsessive quality. Honestly, later stuff like 'You Can't Go Home Again' deals with the South too, but it’s from a more disillusioned, adult perspective. For the pure, youthful, overwhelming sensory portrait, 'Look Homeward, Angel' is the one.