The main characters in 'Summer Sisters' are Caitlin Somers and Victoria Leonard, two girls from wildly different backgrounds who form an intense friendship during summers in Martha's Vineyard. Caitlin is the bold, charismatic one—wealthy, rebellious, and magnetic, drawing people into her orbit effortlessly. Vix is quieter, more introspective, from a working-class family, and often plays the role of Caitlin's loyal shadow. Their dynamic shifts over the years as they grow up, with Caitlin's unpredictability clashing against Vix's need for stability. The novel explores how their friendship weathers jealousy, betrayal, and the complexities of adulthood. Other key figures include Caitlin's brother Bru, who becomes entangled in their emotional lives, and Vix's eventual love interest, who forces her to choose between loyalty and independence.