I get a weird thrill from monsters that are stitched-together Frankensteins of nature, so when people ask which films put a chimera front-and-center, I mentally line them up like trading cards. Biggest and most obvious modern example is 'Jurassic World' — the Indominus rex is literally presented as a lab-made hybrid, a genetic Frankenstein of various species engineered to be terrifying, and it drives the whole movie's conflict. Its spiritual sequel threat, the Indoraptor in 'Jurassic World: Fallen Kingdom,' is another manufactured predator designed as a weapon, blending raptor cunning with engineered aggression.
If you like more biological horror than blockbuster dinos, 'Splice' nails the eerie, intimate side of chimera storytelling. Dren is created from human and animal DNA, and the film spends most of its time watching that hybrid evolve emotionally and physically into something dangerous. Similarly, 'Species' features Sil, a human-alien hybrid whose existence raises all the alarm-bell issues about playing God and sexualized monstrousness.
Going older and classic, the whole Dr. Moreau lineage is foundational — both 'Island of Dr. Moreau' adaptations (the 1932 'Island of Lost Souls' and the 1996 version) center on human-animal hybrids, the Beast Folk, as antagonists borne of mad science. You can also count the original 'Frankenstein' and many of its retellings in the chimera column: a body assembled from parts of many humans, animated into something other. For a weird museum-monster take, 'The Relic' features the Kothoga, a creature assembled by disease and evolution that feels like a patchwork predator. Each of these films treats chimera differently — as weapon, as experiment, as moral mirror — and that's why they stick with me.