The main conflict in 'Blood on the Moon' revolves around a brutal power struggle between vampire clans in a dystopian city. The protagonist, a half-human half-vampire hybrid, gets caught in the crossfire when he discovers a conspiracy to overthrow the ruling council. The older vampires want to maintain their dominance by suppressing human rebellions, while younger factions believe integrating with humans is the only way to survive. Personal stakes skyrocket when the protagonist's human sister gets kidnapped by a radical vampire group. The tension escalates into all-out war, with betrayals, secret alliances, and terrifying ancient vampire weapons being unleashed. The core conflict questions whether different species can coexist or if one must inevitably dominate the other.